Claversal 500 mg
Active ingredient: Mesalazine
Application according to the manufacturer
• Acute exacerbations in chronic inflammatory bowel diseases like ulcerative colitis and Crohn's disease
Dosage
It is one tablet three times daily Claversal take 500th For acute treatment is to increase the dose to three tablets three times daily Claversal 500 possible. The tablets should be about one hour before meals be swallowed whole with plenty of fluid.
Contraindications
The following provides information on contraindications for the application of Claversal 500mg tablets in general, pregnancy and lactation and in children. Please note that depending on the contraindications of the drug dosage form (eg tablet, spray, ointment) may be different.
When Claversal 500mg tablets may not be used?
This medicine should not be used in
• Hypersensitivity to aminosalicylates
• severe liver problems
• severe kidney disease
• Stomach and duodenal ulcers
• increased bleeding tendency.
What should I watch for pregnancy and breastfeeding?
The effects of mesalazine on pregnant women have not been adequately studied. Therefore, the drug will only be used in the form of suppositories or Rektalschaum, if it considers necessary for the doctor.
Mesalazine is used by breastfeeding mothers, it is reflected in breast milk. The active ingredient is absorbed by the baby with the milk and causes diarrhea. Does the doctor treating the mother for absolutely necessary, therefore, should be weaned.
What has to be considered in children?
Tablets and suppositories with mesalazine should not be used in children.
The use of mesalazine enemas is permitted only in children aged six years. In this case, they only receive half the adult dosage.
A Rektalschaum with mesalazine may be used in children from the age of 12.
Side effects
What side effects can have the active ingredient mesalazine 500mg tablets in Claversal? The following is the most important information on possible known side effects of mesalazine 500mg tablets in Claversal. These side effects must not occur, but they can. Because each person reacts differently to medications. Please also note that the side effects in type and number depending on the dosage form of the drug (eg, tablet, spray, ointment) may be different.
Rare side effects:
Diarrhea, abdominal pain, flatulence, nausea and vomiting, headache, dizziness
Very rare or isolated side effects:
Fever, hypersensitivity reactions, shortness of breath, inflammation of the pancreas, heart inflammation, pericarditis, muscle pain, joint pain, changes in blood count, liver function disorders, liver inflammation, renal disorders, itching, hair loss
Interaction
What interactions of the active ingredient mesalazine 500mg tablets are known in Claversal? Please note that the interactions depending on the dosage form of the drug (eg, tablet, spray, ointment) may be different.
The effect of coagulation inhibitors (anticoagulants) such as warfarin or warfarin is enhanced by mesalazine. This results in an increased risk of bleeding in the stomach and intestines.
When co-administered with glucocorticoids and mesalazine may experience side effects such as stomach ulcers.
Mesalazine enhanced the hypoglycaemic effect of oral antidiabetics such as sulfonylureas and descendants.
Together with mesalazine increased the toxic effects of cancer and rheumatic agent methotrexate.
Renal function may be impaired by the interaction of mesalazine with the combination of probenecid and sulfinpyrazone + spironolactone + furosemide.
Warnings & Precautions
• The blood and urine tests should be monitored regularly by the doctor.
• If seizures occur during therapy, acute abdominal pain, fever, severe headache and rash, the treatment should be discontinued immediately.
• In patients with impaired lung function or asthma is a very careful medical surveillance.
• Control of urea and creatinine
• storage instructions.
Medicines may cause allergic reactions. Signs of this can be: skin redness, sneezing, itching, mucous membrane swelling, itching and redness of the eyes, narrowing of the airways (asthma). In rare cases, can lead to allergic shock with unconsciousness.
If you notice signs of an allergic reaction, notify a doctor immediately.
Other ingredients
The following non-active ingredients are contained in the drug:
• colloidal silicon dioxide
• microcrystalline cellulose
• povidone
• talc
• calcium
• carmellose sodium
• E 172
• Eudragit L
• Eudragit S.
• dyes E 171
• glycine
• macrogol 6000
Will act Claversal 500mg tablets
Claversal 500mg tablets contain the active ingredient mesalazine. Below you can learn more about areas of application and mode of action of mesalazine. You should also read the information on the drug class aminosalicylates, which belongs to the drug mesalazine.
Application of the active ingredient: Mesalazine
Mesalazine is used in inflammatory bowel diseases like Crohn's disease and ulcerative colitis. Treatment goal is the healing of the inflammation and alleviation of symptoms caused by them: pain and diarrhea.
The administration of Melsalazin can be done either by taking in pill form as well as by insertion into the intestine in the form of suppositories, or enemas Rektalschaum.
Mode of action of mesalazine
Patients with chronic inflammatory bowel disorders suffer primarily from severe abdominal pain and diarrhea. Typically the disease does not extend uniformly. It alternate periods of high inflammatory activity and severe discomfort with split times, in which the patients are almost free of symptoms. In those affected greatly increased concentrations of endogenous inflammation-promoting substances such as prostaglandins, leukotrienes and interleukins are found in the intestinal mucosa.
Like all drugs from the group consisting of aminosalicylates mesalazine blocked the production of these inflammatory mediators and thus is effective anti-inflammatory. With the drug, the symptoms in an acute phase of disease can be fought, but it can also prevent the seizure-free period of relapses.
As mesalazine is not included in the rest of the body, it acts only locally in the gut and has few side effects.
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